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Phospholipases cleave a class of lipids called phosphatidylinositols, sarms side effects for females. Gs tend to activate phospholipase C that generates inositol 3-phosphate (IP3) and diacylglycerorl (DAG). IP3 binds to calcium channels in the endoplasmic reticulum causing them to open and release calcium into the cytoplasm. Many cellular events are regulated by calcium levels including muscle contraction. 
 
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